Mice or men?

Of mice and men, or: a pill for emphysema?

Accessible online at: www.karger.com/res When John Steinbeck wrote his great novel Of Mice and Men (1937) he certainly did not intend to engage in the endless story of the proper choice of an experimental animal as an appropriate model of human pathophysiology. In fact, promising results of experiments on one species are often nullified by negative results in another species in an otherwise ver...

Mice are not men.

Transforming Men into Mice

Many people (including ourselves) believe that transformations of humans into mice happen only in fairy tales. However, despite some di erences in appearance and habits, men and mice are genetically very similar. In the pioneering paper, Nadeau and Taylor, 1984 estimated that surprisingly few genomic rearrangements (178 39) happened since the divergence of human and mouse 80 million years ago. ...

Of mice, men, and hormones.

Incidence of cardiovascular disease is consistently greater in men than in women during the first five decades of life.1 Because this gender disparity begins early in life, it is likely that a combination of genetic, environmental (possibly intrauterine) factors, and actions of sex-specific hormones contribute to the disease process (see Nagel and vom Saal2). However, most research has focused ...

Irradiation of Mice and Men

A great responsibility is borne by those who determine what level of radiation exposure to man can be regarded as permissable in modern civilization. A value set too high could lead to an excessive load of deleterious mutations in the human genome that we all carry, while a value set too low will prove costly and time consuming to maintain. This book is written by Dr. John F. Loutit who played ...